Predicted to enable transcription coactivator binding activity. Involved in negative regulation of Wnt signaling pathway; negative regulation of cell growth; and negative regulation of hippo signaling. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for VGLL4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VGLL4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VGLL4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:11,495,996–11,496,571 | 224.4 kb | Distal (>10kb) Multiome | 188 | |
| chr3:11,591,427–11,591,889 | 129.2 kb | Distal (>10kb) Multiome | 294 | |
| chr3:11,638,230–11,638,504 | 5.4 kb | Proximal (<10kb) | 53 | |
| chr3:11,642,773–11,643,110 | 804 bp | At TSS | 691 | |
| chr3:11,643,590–11,644,257 | 76.8 kb | Distal (>10kb) Multiome | 657 | |
| chr3:11,713,608–11,714,036 | 5.6 kb | Proximal (<10kb) | 18 | |
| chr3:11,718,742–11,720,867 | 1.1 kb | Proximal (<10kb) Multiome | 845 | |
| chr3:11,770,323–11,771,120 | 49.9 kb | Distal (>10kb) Multiome | 481 | |
| chr3:11,846,284–11,847,247 | 126.2 kb | Distal (>10kb) Multiome | 833 | |
| chr3:12,003,835–12,005,168 | 283.6 kb | Distal (>10kb) Multiome | 297 |
Genomic view of the VGLL4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.