Predicted to enable phosphatidylinositol-5-phosphate binding activity. Involved in negative regulation of SMAD protein signal transduction and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in endomembrane system. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for VEPH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VEPH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VEPH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:157,159,206–157,161,193 | 339.3 kb | Distal (>10kb) Multiome HiCAR | 1215 | |
| chr3:157,174,174–157,175,938 | 324.5 kb | Distal (>10kb) Multiome HiCAR | 1138 | |
| chr3:157,347,437–157,348,263 | 151.6 kb | Distal (>10kb) Multiome HiCAR | 150 | |
| chr3:157,437,270–157,438,724 | 61.7 kb | Distal (>10kb) Multiome | 510 | |
| chr3:157,493,737–157,493,920 | 5.6 kb | Proximal (<10kb) | 123 | |
| chr3:157,496,595–157,496,758 | 2.8 kb | Proximal (<10kb) | 4 | |
| chr3:157,499,252–157,500,077 | 72 bp | At TSS Multiome | 427 | |
| chr3:157,501,950–157,502,202 | 2.4 kb | Proximal (<10kb) | 39 | |
| chr3:157,503,106–157,503,515 | 3.6 kb | Proximal (<10kb) | 92 | |
| chr3:157,507,536–157,507,862 | 8.0 kb | Proximal (<10kb) | 7 | |
| chr3:157,542,466–157,543,875 | 43.5 kb | Distal (>10kb) Multiome | 320 |
Genomic view of the VEPH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.