This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for VDAC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VDAC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VDAC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:133,786,502–133,787,082 | 217.9 kb | Distal (>10kb) Multiome | 59 | |
| chr5:133,968,103–133,968,907 | 36.0 kb | Distal (>10kb) Multiome | 861 | |
| chr5:134,004,027–134,006,483 | 137 bp | At TSS Multiome | 948 | |
| chr5:134,007,983–134,008,348 | 3.3 kb | Proximal (<10kb) | 98 | |
| chr5:134,039,553–134,040,013 | 35.0 kb | Distal (>10kb) Multiome | 576 | |
| chr5:134,070,573–134,071,963 | 66.6 kb | Distal (>10kb) Multiome | 666 | |
| chr5:134,099,891–134,100,749 | 95.4 kb | Distal (>10kb) Multiome | 227 | |
| chr5:134,101,617–134,102,291 | 97.4 kb | Distal (>10kb) Multiome | 334 | |
| chr5:134,113,043–134,116,112 | 111.0 kb | Distal (>10kb) Multiome | 637 | |
| chr5:134,140,528–134,140,995 | 136.1 kb | Distal (>10kb) Multiome | 342 | |
| chr5:134,176,142–134,177,562 | 172.3 kb | Distal (>10kb) Multiome | 952 | |
| chr5:134,184,086–134,184,650 | 179.7 kb | Distal (>10kb) Multiome | 289 | |
| chr5:134,225,248–134,227,248 | 221.6 kb | Distal (>10kb) Multiome | 1043 |
Genomic view of the VDAC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.