Enables WD40-repeat domain binding activity and cysteine-type deubiquitinase activity. Involved in base-excision repair; monoubiquitinated protein deubiquitination; and positive regulation of canonical Wnt signaling pathway. Located in cytoplasm. Part of SCF ubiquitin ligase complex. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for USP47. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USP47 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USP47, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:11,620,289–11,622,686 | 219.8 kb | Distal (>10kb) Multiome | 554 | |
| chr11:11,691,525–11,692,376 | 150.0 kb | Distal (>10kb) Multiome | 109 | |
| chr11:11,841,165–11,842,766 | 44 bp | At TSS Multiome | 934 | |
| chr11:11,849,332–11,849,510 | 7.4 kb | Proximal (<10kb) | 267 | |
| chr11:11,966,784–11,967,255 | 125.1 kb | Distal (>10kb) Multiome | 217 | |
| chr11:12,007,976–12,009,889 | 167.3 kb | Distal (>10kb) Multiome | 309 | |
| chr11:12,020,024–12,021,109 | 178.7 kb | Distal (>10kb) Multiome | 125 | |
| chr11:12,109,991–12,111,523 | 268.5 kb | Distal (>10kb) Multiome | 611 | |
| chr11:12,201,005–12,201,566 | 359.3 kb | Distal (>10kb) Multiome | 470 |
Genomic view of the USP47 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.