Predicted to enable ISG15-specific peptidase activity. Predicted to be involved in translesion synthesis. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for USP43. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USP43 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USP43, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:9,537,200–9,537,700 | 108.1 kb | Distal (>10kb) Multiome | 104 | |
| chr17:9,538,516–9,539,118 | 106.6 kb | Distal (>10kb) Multiome | 40 | |
| chr17:9,575,548–9,576,139 | 69.7 kb | Distal (>10kb) Multiome | 742 | |
| chr17:9,576,486–9,577,434 | 68.8 kb | Distal (>10kb) Multiome | 299 | |
| chr17:9,644,530–9,646,203 | 816 bp | At TSS Multiome | 793 | |
| chr17:9,811,573–9,812,280 | 166.4 kb | Distal (>10kb) Multiome | 42 |
Genomic view of the USP43 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.