Enables deubiquitinase activity; enzyme binding activity; and transcription coactivator activity. Contributes to histone H4 acetyltransferase activity. Involved in several processes, including G2/M transition of mitotic cell cycle; protein deubiquitination; and regulation of gene expression. Part of SAGA complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for USP22. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USP22 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USP22, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:20,843,455–20,844,334 | 199.0 kb | Distal (>10kb) Multiome | 77 | |
| chr17:20,868,077–20,868,766 | 174.6 kb | Distal (>10kb) Multiome | 123 | |
| chr17:20,908,196–20,908,861 | 134.4 kb | Distal (>10kb) Multiome | 516 | |
| chr17:20,992,594–20,993,594 | 49.9 kb | Distal (>10kb) Multiome | 237 | |
| chr17:21,040,275–21,040,454 | 1.8 kb | Proximal (<10kb) | 224 | |
| chr17:21,041,818–21,044,206 | 279 bp | At TSS Multiome | 1019 | |
| chr17:21,098,970–21,099,982 | 56.3 kb | Distal (>10kb) Multiome | 514 | |
| chr17:21,106,347–21,107,024 | 63.6 kb | Distal (>10kb) Multiome | 32 | |
| chr17:21,108,710–21,109,234 | 65.9 kb | Distal (>10kb) Multiome | 13 | |
| chr17:21,126,572–21,127,535 | 84.0 kb | Distal (>10kb) Multiome | 707 | |
| chr17:21,213,670–21,215,538 | 171.4 kb | Distal (>10kb) Multiome | 849 | |
| chr17:21,252,548–21,253,969 | 210.4 kb | Distal (>10kb) Multiome | 558 | |
| chr17:21,275,381–21,276,434 | 232.9 kb | Distal (>10kb) Multiome | 671 | |
| chr17:21,280,014–21,280,480 | 237.2 kb | Distal (>10kb) Multiome | 435 | |
| chr17:21,283,767–21,285,795 | 241.6 kb | Distal (>10kb) Multiome | 672 | |
| chr17:21,322,850–21,323,584 | 280.1 kb | Distal (>10kb) Multiome | 172 |
Genomic view of the USP22 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.