This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for USP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:62,177,448–62,178,351 | 259.2 kb | Distal (>10kb) Multiome HiCAR | 70 | |
| chr1:62,194,263–62,195,303 | 242.3 kb | Distal (>10kb) Multiome | 231 | |
| chr1:62,198,057–62,199,070 | 238.6 kb | Distal (>10kb) Multiome | 351 | |
| chr1:62,286,714–62,287,329 | 150.1 kb | Distal (>10kb) Multiome | 188 | |
| chr1:62,318,171–62,319,540 | 118.0 kb | Distal (>10kb) Multiome | 432 | |
| chr1:62,327,423–62,328,065 | 109.4 kb | Distal (>10kb) Multiome | 254 | |
| chr1:62,435,836–62,437,694 | 526 bp | At TSS Multiome | 1064 | |
| chr1:62,687,521–62,689,077 | 251.3 kb | Distal (>10kb) Multiome | 801 |
Genomic view of the USP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.