UROD

uroporphyrinogen decarboxylase

This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010]

Member of: DE-4

Biological processes 21 terms

cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)heme A biosynthetic process (GO:0006784)heme B biosynthetic process (GO:0006785)heme B biosynthetic process (GO:0006785)heme biosynthetic process (GO:0006783)heme biosynthetic process (GO:0006783)nucleoplasm (GO:0005654)porphyrin-containing compound biosynthetic process (GO:0006779)porphyrin-containing compound catabolic process (GO:0006787)porphyrin-containing compound metabolic process (GO:0006778)protein binding (GO:0005515)protoporphyrinogen IX biosynthetic process (GO:0006782)protoporphyrinogen IX biosynthetic process (GO:0006782)uroporphyrinogen decarboxylase activity (GO:0004853)uroporphyrinogen decarboxylase activity (GO:0004853)uroporphyrinogen decarboxylase activity (GO:0004853)uroporphyrinogen decarboxylase activity (GO:0004853)

Expression (TPM)

TFs regulating UROD 0 TFs

Transcription factors with Perturb-seq knockdown data for UROD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UROD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to UROD

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UROD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:44,720,791–44,722,329	290.5 kb	Distal (>10kb) Multiome	1059
chr1:44,730,465–44,731,848	281.2 kb	Distal (>10kb) Multiome	1164
chr1:44,739,368–44,740,265	272.5 kb	Distal (>10kb) Multiome	828
chr1:44,775,008–44,776,007	236.7 kb	Distal (>10kb) Multiome	1041
chr1:44,783,907–44,784,940	227.8 kb	Distal (>10kb) Multiome HiCAR	497
chr1:44,786,163–44,786,815	225.8 kb	Distal (>10kb) Multiome HiCAR	616
chr1:44,799,477–44,801,039	212.1 kb	Distal (>10kb) Multiome HiCAR	1017
chr1:44,807,115–44,808,920	203.6 kb	Distal (>10kb) Multiome HiCAR	987
chr1:44,812,965–44,814,105	198.4 kb	Distal (>10kb) Multiome	349
chr1:44,818,937–44,820,693	192.3 kb	Distal (>10kb) Multiome HiCAR	1101
chr1:44,842,822–44,843,695	168.9 kb	Distal (>10kb) Multiome HiCAR	539
chr1:44,986,311–44,986,894	25.6 kb	Distal (>10kb) Multiome	979
chr1:45,010,856–45,013,180	10 bp	At TSS Multiome	909
chr1:45,014,536–45,014,759	2.3 kb	Proximal (<10kb)	267
chr1:45,018,707–45,018,961	6.5 kb	Proximal (<10kb)	178
chr1:45,205,664–45,207,097	194.3 kb	Distal (>10kb) Multiome	691
chr1:45,216,712–45,217,234	204.8 kb	Distal (>10kb) Multiome HiCAR	42
chr1:45,303,203–45,304,881	291.6 kb	Distal (>10kb) Multiome HiCAR	1034
chr1:45,315,837–45,316,870	303.9 kb	Distal (>10kb) Multiome HiCAR	113
chr1:45,317,165–45,317,643	305.2 kb	Distal (>10kb) Multiome HiCAR	7
chr1:45,321,623–45,322,180	309.5 kb	Distal (>10kb) Multiome HiCAR	54
chr1:45,326,327–45,328,092	314.7 kb	Distal (>10kb) Multiome HiCAR	382
chr1:45,339,505–45,340,694	327.9 kb	Distal (>10kb) Multiome HiCAR	951
chr1:45,490,605–45,491,773	479.1 kb	Distal (>10kb) Multiome HiCAR	900
chr1:45,499,499–45,500,620	487.9 kb	Distal (>10kb) Multiome HiCAR	831

Genome Browser

Genomic view of the UROD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.