This gene encodes the smallest known component of the ubiquinol-cytochrome c reductase complex, which forms part of the mitochondrial respiratory chain. The encoded protein may function as a binding factor for the iron-sulfur protein in this complex. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for UQCR11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UQCR11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UQCR11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:1,354,303–1,355,411 | 250.6 kb | Distal (>10kb) Multiome | 688 | |
| chr19:1,383,122–1,384,333 | 221.8 kb | Distal (>10kb) Multiome | 1228 | |
| chr19:1,401,101–1,401,839 | 203.9 kb | Distal (>10kb) Multiome | 540 | |
| chr19:1,406,589–1,408,783 | 198.0 kb | Distal (>10kb) Multiome | 911 | |
| chr19:1,415,008–1,415,721 | 190.0 kb | Distal (>10kb) Multiome | 597 | |
| chr19:1,437,988–1,438,998 | 167.1 kb | Distal (>10kb) Multiome | 1076 | |
| chr19:1,444,785–1,447,383 | 160.2 kb | Distal (>10kb) Multiome | 797 | |
| chr19:1,455,191–1,456,421 | 149.6 kb | Distal (>10kb) Multiome | 491 | |
| chr19:1,468,941–1,469,903 | 136.2 kb | Distal (>10kb) Multiome | 242 | |
| chr19:1,470,088–1,471,597 | 134.7 kb | Distal (>10kb) Multiome | 544 | |
| chr19:1,478,772–1,479,848 | 126.1 kb | Distal (>10kb) Multiome | 857 | |
| chr19:1,489,566–1,491,829 | 114.6 kb | Distal (>10kb) Multiome | 836 | |
| chr19:1,507,230–1,508,699 | 97.3 kb | Distal (>10kb) Multiome | 596 | |
| chr19:1,512,960–1,513,686 | 92.3 kb | Distal (>10kb) Multiome | 541 | |
| chr19:1,523,798–1,524,624 | 81.4 kb | Distal (>10kb) Multiome | 263 | |
| chr19:1,566,277–1,568,916 | 38.7 kb | Distal (>10kb) Multiome | 748 | |
| chr19:1,592,085–1,593,444 | 12.7 kb | Distal (>10kb) Multiome | 883 | |
| chr19:1,604,859–1,606,501 | 189 bp | At TSS Multiome | 902 | |
| chr19:1,651,519–1,653,514 | 47.5 kb | Distal (>10kb) Multiome | 909 | |
| chr19:1,725,307–1,726,101 | 120.3 kb | Distal (>10kb) Multiome | 455 | |
| chr19:1,811,638–1,813,347 | 207.2 kb | Distal (>10kb) Multiome | 782 | |
| chr19:1,826,853–1,827,379 | 221.8 kb | Distal (>10kb) Multiome | 193 | |
| chr19:1,848,048–1,848,953 | 243.2 kb | Distal (>10kb) Multiome | 819 | |
| chr19:1,851,701–1,852,216 | 246.5 kb | Distal (>10kb) Multiome | 115 | |
| chr19:1,855,082–1,856,620 | 250.0 kb | Distal (>10kb) Multiome | 476 | |
| chr19:1,861,439–1,865,723 | 258.5 kb | Distal (>10kb) Multiome | 891 | |
| chr19:1,875,645–1,876,693 | 270.8 kb | Distal (>10kb) Multiome | 887 | |
| chr19:1,885,058–1,885,861 | 280.1 kb | Distal (>10kb) Multiome | 495 | |
| chr19:1,904,556–1,906,084 | 300.0 kb | Distal (>10kb) Multiome | 907 |
Genomic view of the UQCR11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.