Enables mitochondrial ribosome binding activity. Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Is active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UQCC5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UQCC5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UQCC5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:52,238,767–52,239,716 | 297.4 kb | Distal (>10kb) Multiome | 763 | |
| chr3:52,245,446–52,246,450 | 290.6 kb | Distal (>10kb) Multiome | 553 | |
| chr3:52,277,664–52,279,184 | 257.9 kb | Distal (>10kb) Multiome | 844 | |
| chr3:52,287,499–52,288,336 | 248.7 kb | Distal (>10kb) Multiome | 778 | |
| chr3:52,409,430–52,411,187 | 126.3 kb | Distal (>10kb) Multiome | 813 | |
| chr3:52,444,941–52,445,411 | 91.5 kb | Distal (>10kb) Multiome | 426 | |
| chr3:52,455,213–52,455,878 | 81.1 kb | Distal (>10kb) Multiome | 630 | |
| chr3:52,518,607–52,519,389 | 17.6 kb | Distal (>10kb) Multiome | 176 | |
| chr3:52,532,907–52,533,288 | 723 bp | At TSS | 349 | |
| chr3:52,533,486–52,535,316 | 2.7 kb | Proximal (<10kb) Multiome | 648 | |
| chr3:52,536,232–52,537,450 | 68 bp | At TSS Multiome | 901 | |
| chr3:52,685,427–52,686,463 | 149.2 kb | Distal (>10kb) Multiome | 933 | |
| chr3:52,705,495–52,706,415 | 169.4 kb | Distal (>10kb) Multiome | 862 | |
| chr3:52,714,354–52,715,301 | 178.1 kb | Distal (>10kb) Multiome | 224 | |
| chr3:52,770,467–52,771,332 | 234.3 kb | Distal (>10kb) Multiome | 788 |
Genomic view of the UQCC5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.