UQCC2

ubiquinol-cytochrome c reductase complex assembly factor 2 | Cbp6, M19, MGC14833, bA6B20.2, C6orf125, MNF1

This gene encodes a nucleoid protein localized to the mitochondria inner membrane. The encoded protein affects regulation of insulin secretion, mitochondrial ATP production, and myogenesis through modulation of mitochondrial respiratory chain activity. [provided by RefSeq, Oct 2012]

Member of: DE-1 DE-1.54 Developmental clusters: GC5

Biological processes 19 terms

mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial intermembrane space (GO:0005758)mitochondrial intermembrane space (GO:0005758)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial nucleoid (GO:0042645)mitochondrial nucleoid (GO:0042645)mitochondrial respiratory chain complex III assembly (GO:0034551)mitochondrial respiratory chain complex III assembly (GO:0034551)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)positive regulation of mitochondrial translation (GO:0070131)protein binding (GO:0005515)regulation of insulin secretion (GO:0050796)regulation of oxidative phosphorylation (GO:0002082)regulation of skeletal muscle cell differentiation (GO:2001014)

Expression (TPM)

TFs regulating UQCC2 0 TFs

Transcription factors with Perturb-seq knockdown data for UQCC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UQCC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to UQCC2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UQCC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:33,417,606–33,419,249	293.4 kb	Distal (>10kb) Multiome	973
chr6:33,419,793–33,420,532	291.5 kb	Distal (>10kb) Multiome	162
chr6:33,425,590–33,426,362	285.8 kb	Distal (>10kb) Multiome	665
chr6:33,431,024–33,432,096	280.5 kb	Distal (>10kb) Multiome	337
chr6:33,454,074–33,454,852	257.2 kb	Distal (>10kb) Multiome	906
chr6:33,547,185–33,548,324	164.0 kb	Distal (>10kb) Multiome	155
chr6:33,570,899–33,571,638	140.3 kb	Distal (>10kb) Multiome	755
chr6:33,579,935–33,580,700	131.4 kb	Distal (>10kb) Multiome HiCAR	639
chr6:33,592,764–33,593,449	118.7 kb	Distal (>10kb) Multiome	224
chr6:33,620,828–33,622,474	89.7 kb	Distal (>10kb) Multiome	594
chr6:33,632,607–33,634,721	79.0 kb	Distal (>10kb) Multiome	600
chr6:33,711,017–33,712,173	4 bp	At TSS Multiome	943
chr6:33,771,283–33,772,101	60.0 kb	Distal (>10kb) Multiome	478
chr6:33,788,007–33,789,360	77.5 kb	Distal (>10kb) Multiome	999
chr6:33,828,845–33,829,529	117.3 kb	Distal (>10kb) Multiome	97
chr6:33,950,527–33,951,235	239.1 kb	Distal (>10kb) Multiome	82

Genome Browser

Genomic view of the UQCC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.