The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for UPK1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UPK1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UPK1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:119,034,159–119,035,267 | 138.8 kb | Distal (>10kb) Multiome | 570 | |
| chr3:119,173,189–119,173,912 | at TSS | At TSS | 150 | |
| chr3:119,176,650–119,176,873 | 3.1 kb | Proximal (<10kb) | 84 | |
| chr3:119,206,295–119,207,798 | 33.4 kb | Distal (>10kb) Multiome | 256 | |
| chr3:119,210,998–119,211,738 | 37.8 kb | Distal (>10kb) Multiome | 234 | |
| chr3:119,240,068–119,241,279 | 67.3 kb | Distal (>10kb) Multiome | 820 | |
| chr3:119,241,393–119,241,941 | 68.1 kb | Distal (>10kb) Multiome | 393 | |
| chr3:119,293,740–119,295,412 | 120.5 kb | Distal (>10kb) Multiome | 540 | |
| chr3:119,322,394–119,324,118 | 149.4 kb | Distal (>10kb) Multiome | 824 | |
| chr3:119,349,421–119,349,961 | 176.0 kb | Distal (>10kb) Multiome | 181 | |
| chr3:119,417,868–119,418,544 | 244.7 kb | Distal (>10kb) Multiome | 156 | |
| chr3:119,463,124–119,464,243 | 290.1 kb | Distal (>10kb) Multiome | 902 | |
| chr3:119,468,550–119,469,486 | 295.4 kb | Distal (>10kb) Multiome | 832 |
Genomic view of the UPK1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.