This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for UNG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UNG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UNG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:108,560,717–108,561,713 | 536.4 kb | Distal (>10kb) Multiome HiCAR | 703 | |
| chr12:108,561,872–108,563,300 | 535.0 kb | Distal (>10kb) Multiome HiCAR | 772 | |
| chr12:108,802,154–108,802,651 | 295.3 kb | Distal (>10kb) Multiome | 135 | |
| chr12:108,856,753–108,858,260 | 239.9 kb | Distal (>10kb) Multiome | 698 | |
| chr12:109,052,237–109,053,072 | 45.0 kb | Distal (>10kb) Multiome | 965 | |
| chr12:109,069,700–109,070,229 | 27.6 kb | Distal (>10kb) Multiome | 118 | |
| chr12:109,093,224–109,093,868 | 4.1 kb | Proximal (<10kb) Multiome | 998 | |
| chr12:109,097,190–109,098,740 | 447 bp | At TSS Multiome | 758 | |
| chr12:109,110,997–109,111,481 | 13.6 kb | Distal (>10kb) Multiome | 593 | |
| chr12:109,154,096–109,155,355 | 57.3 kb | Distal (>10kb) Multiome | 595 | |
| chr12:109,308,986–109,310,221 | 211.7 kb | Distal (>10kb) Multiome | 331 |
Genomic view of the UNG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.