Predicted to enable calmodulin binding activity and syntaxin-1 binding activity. Predicted to be involved in glutamatergic synaptic transmission and regulated exocytosis. Predicted to be located in presynaptic active zone. Predicted to be active in several cellular components, including axon terminus; parallel fiber to Purkinje cell synapse; and synaptic vesicle membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for UNC13C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UNC13C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UNC13C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:53,758,987–53,760,031 | 218.8 kb | Distal (>10kb) Multiome | 192 | |
| chr15:53,810,311–53,811,031 | 167.8 kb | Distal (>10kb) Multiome | 127 | |
| chr15:53,918,170–53,918,968 | 60.0 kb | Distal (>10kb) Multiome | 185 | |
| chr15:53,976,916–53,977,258 | 1.2 kb | Proximal (<10kb) | 145 | |
| chr15:53,978,142–53,978,800 | at TSS | At TSS | 176 | |
| chr15:55,196,449–55,197,580 | 1218.6 kb | Distal (>10kb) Multiome HiCAR | 812 | |
| chr15:55,288,999–55,291,001 | 1312.0 kb | Distal (>10kb) Multiome HiCAR | 744 | |
| chr15:55,318,855–55,319,494 | 1340.8 kb | Distal (>10kb) Multiome HiCAR | 875 | |
| chr15:55,587,537–55,588,889 | 1609.9 kb | Distal (>10kb) Multiome HiCAR | 432 |
Genomic view of the UNC13C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.