This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for UNC119. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UNC119 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UNC119, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:28,317,975–28,319,646 | 233.6 kb | Distal (>10kb) Multiome | 858 | |
| chr17:28,321,010–28,321,937 | 231.2 kb | Distal (>10kb) Multiome | 25 | |
| chr17:28,335,024–28,336,772 | 217.0 kb | Distal (>10kb) Multiome | 933 | |
| chr17:28,357,059–28,357,929 | 195.1 kb | Distal (>10kb) Multiome | 878 | |
| chr17:28,371,118–28,372,519 | 181.1 kb | Distal (>10kb) Multiome | 532 | |
| chr17:28,381,316–28,381,844 | 171.1 kb | Distal (>10kb) Multiome | 159 | |
| chr17:28,405,673–28,406,384 | 146.7 kb | Distal (>10kb) Multiome | 591 | |
| chr17:28,466,531–28,467,034 | 85.8 kb | Distal (>10kb) Multiome | 179 | |
| chr17:28,548,230–28,548,444 | 4.2 kb | Proximal (<10kb) | 238 | |
| chr17:28,551,965–28,553,140 | 5 bp | At TSS Multiome | 557 | |
| chr17:28,570,861–28,571,983 | 18.9 kb | Distal (>10kb) Multiome | 701 | |
| chr17:28,576,649–28,577,524 | 24.4 kb | Distal (>10kb) Multiome | 652 | |
| chr17:28,598,491–28,599,842 | 46.5 kb | Distal (>10kb) Multiome | 810 | |
| chr17:28,621,936–28,622,562 | 69.7 kb | Distal (>10kb) Multiome | 55 | |
| chr17:28,644,541–28,645,596 | 92.6 kb | Distal (>10kb) Multiome | 795 | |
| chr17:28,661,635–28,662,527 | 109.5 kb | Distal (>10kb) Multiome | 809 | |
| chr17:28,710,720–28,712,813 | 158.8 kb | Distal (>10kb) Multiome | 892 | |
| chr17:28,717,030–28,718,784 | 165.3 kb | Distal (>10kb) Multiome | 492 | |
| chr17:28,718,918–28,720,313 | 167.2 kb | Distal (>10kb) Multiome | 927 | |
| chr17:28,724,652–28,729,474 | 174.4 kb | Distal (>10kb) Multiome | 1286 | |
| chr17:28,743,083–28,744,926 | 191.4 kb | Distal (>10kb) Multiome | 991 | |
| chr17:28,745,076–28,746,436 | 193.0 kb | Distal (>10kb) Multiome | 568 | |
| chr17:28,749,859–28,750,549 | 197.6 kb | Distal (>10kb) Multiome | 550 | |
| chr17:28,811,615–28,812,945 | 259.9 kb | Distal (>10kb) Multiome | 699 | |
| chr17:28,842,307–28,843,098 | 290.2 kb | Distal (>10kb) Multiome | 717 |
Genomic view of the UNC119 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.