UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
Transcription factors with Perturb-seq knockdown data for UGGT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UGGT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UGGT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:127,810,532–127,811,650 | 280.0 kb | Distal (>10kb) Multiome | 948 | |
| chr2:127,857,714–127,858,658 | 233.0 kb | Distal (>10kb) Multiome | 924 | |
| chr2:127,859,716–127,860,274 | 231.3 kb | Distal (>10kb) Multiome | 286 | |
| chr2:127,885,860–127,886,795 | 204.9 kb | Distal (>10kb) Multiome | 331 | |
| chr2:128,026,821–128,028,727 | 63.8 kb | Distal (>10kb) Multiome | 872 | |
| chr2:128,090,830–128,091,736 | 20 bp | At TSS Multiome | 987 | |
| chr2:128,195,741–128,196,874 | 105.2 kb | Distal (>10kb) Multiome | 365 | |
| chr2:128,232,712–128,234,252 | 142.4 kb | Distal (>10kb) Multiome | 834 | |
| chr2:128,234,465–128,235,115 | 143.6 kb | Distal (>10kb) Multiome | 66 | |
| chr2:128,260,688–128,261,545 | 169.8 kb | Distal (>10kb) Multiome | 352 | |
| chr2:128,317,236–128,318,078 | 226.3 kb | Distal (>10kb) Multiome | 437 | |
| chr2:128,318,609–128,319,523 | 227.8 kb | Distal (>10kb) Multiome | 550 | |
| chr2:128,321,402–128,322,797 | 230.8 kb | Distal (>10kb) Multiome | 727 | |
| chr2:128,378,778–128,379,757 | 288.1 kb | Distal (>10kb) Multiome | 353 |
Genomic view of the UGGT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.