Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; ubiquitin binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UBXN7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBXN7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBXN7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:196,207,804–196,208,801 | 224.2 kb | Distal (>10kb) Multiome | 300 | |
| chr3:196,273,588–196,274,153 | 158.6 kb | Distal (>10kb) Multiome | 95 | |
| chr3:196,287,125–196,288,362 | 144.7 kb | Distal (>10kb) Multiome | 979 | |
| chr3:196,317,553–196,318,672 | 114.2 kb | Distal (>10kb) Multiome | 830 | |
| chr3:196,431,516–196,433,176 | 68 bp | At TSS Multiome | 851 | |
| chr3:196,503,288–196,504,272 | 71.4 kb | Distal (>10kb) Multiome | 897 | |
| chr3:196,528,585–196,529,088 | 96.5 kb | Distal (>10kb) Multiome | 425 | |
| chr3:196,568,218–196,569,450 | 136.3 kb | Distal (>10kb) Multiome | 853 | |
| chr3:196,631,880–196,633,250 | 200.1 kb | Distal (>10kb) Multiome | 879 | |
| chr3:196,639,198–196,640,059 | 207.2 kb | Distal (>10kb) Multiome | 438 | |
| chr3:196,665,925–196,666,686 | 233.8 kb | Distal (>10kb) Multiome | 439 | |
| chr3:196,711,809–196,713,001 | 280.0 kb | Distal (>10kb) Multiome | 782 |
Genomic view of the UBXN7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.