The degradation of many proteins is carried out by the ubiquitin pathway in which proteins are targeted for degradation by covalent conjugation of the polypeptide ubiquitin. This gene encodes a protein that belongs to the ubiquitin family of proteins. The encoded protein is thought to regulate E2 ubiquitin conjugating enzymes belonging to the UBE2D family. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for UBTD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBTD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBTD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:97,291,972–97,293,103 | 206.3 kb | Distal (>10kb) Multiome | 945 | |
| chr10:97,318,840–97,320,386 | 179.8 kb | Distal (>10kb) Multiome | 836 | |
| chr10:97,333,472–97,335,742 | 164.0 kb | Distal (>10kb) Multiome | 917 | |
| chr10:97,336,929–97,337,706 | 161.6 kb | Distal (>10kb) Multiome | 362 | |
| chr10:97,400,817–97,401,691 | 97.6 kb | Distal (>10kb) Multiome | 644 | |
| chr10:97,407,246–97,407,739 | 91.5 kb | Distal (>10kb) Multiome | 539 | |
| chr10:97,418,830–97,419,461 | 79.8 kb | Distal (>10kb) Multiome | 323 | |
| chr10:97,425,050–97,426,796 | 72.8 kb | Distal (>10kb) Multiome | 715 | |
| chr10:97,445,521–97,446,585 | 52.8 kb | Distal (>10kb) Multiome | 802 | |
| chr10:97,495,201–97,495,487 | 3.4 kb | Proximal (<10kb) | 53 | |
| chr10:97,497,718–97,499,773 | 233 bp | At TSS Multiome | 967 | |
| chr10:97,553,598–97,554,047 | 54.8 kb | Distal (>10kb) Multiome | 340 | |
| chr10:97,632,775–97,633,915 | 134.5 kb | Distal (>10kb) Multiome | 725 | |
| chr10:97,640,236–97,641,335 | 141.7 kb | Distal (>10kb) Multiome | 712 | |
| chr10:97,686,724–97,687,987 | 188.5 kb | Distal (>10kb) Multiome | 993 | |
| chr10:97,713,223–97,715,263 | 214.9 kb | Distal (>10kb) Multiome | 639 | |
| chr10:97,736,595–97,737,824 | 238.2 kb | Distal (>10kb) Multiome | 1009 | |
| chr10:97,771,123–97,772,389 | 272.8 kb | Distal (>10kb) Multiome | 356 | |
| chr10:97,788,725–97,789,448 | 290.2 kb | Distal (>10kb) Multiome | 398 |
Genomic view of the UBTD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.