Transcription factors with Perturb-seq knockdown data for UBL7-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBL7-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBL7-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:74,202,453–74,203,387 | 258.4 kb | Distal (>10kb) Multiome | 381 | |
| chr15:74,208,748–74,209,470 | 252.2 kb | Distal (>10kb) Multiome | 233 | |
| chr15:74,245,168–74,245,975 | 215.7 kb | Distal (>10kb) Multiome | 278 | |
| chr15:74,291,174–74,291,950 | 169.8 kb | Distal (>10kb) Multiome | 773 | |
| chr15:74,354,072–74,354,610 | 107.0 kb | Distal (>10kb) Multiome | 15 | |
| chr15:74,365,599–74,366,233 | 95.3 kb | Distal (>10kb) Multiome | 441 | |
| chr15:74,373,469–74,375,034 | 86.9 kb | Distal (>10kb) Multiome HiCAR | 745 | |
| chr15:74,433,053–74,434,500 | 27.4 kb | Distal (>10kb) Multiome | 695 | |
| chr15:74,460,798–74,461,761 | 65 bp | At TSS Multiome | 925 | |
| chr15:74,531,382–74,531,884 | 70.4 kb | Distal (>10kb) Multiome | 217 | |
| chr15:74,540,389–74,542,119 | 79.9 kb | Distal (>10kb) Multiome | 838 | |
| chr15:74,598,102–74,598,966 | 137.2 kb | Distal (>10kb) Multiome | 689 | |
| chr15:74,614,343–74,616,348 | 154.5 kb | Distal (>10kb) Multiome | 1019 | |
| chr15:74,695,758–74,696,387 | 234.8 kb | Distal (>10kb) Multiome | 775 | |
| chr15:74,720,336–74,720,840 | 259.4 kb | Distal (>10kb) Multiome | 16 | |
| chr15:74,725,773–74,726,537 | 264.9 kb | Distal (>10kb) Multiome | 607 | |
| chr15:74,759,107–74,760,837 | 299.1 kb | Distal (>10kb) Multiome | 637 |
Genomic view of the UBL7-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.