UBE2T
ubiquitin conjugating enzyme E2 T | FANCT, HSPC150

The protein encoded by this gene catalyzes the covalent attachment of ubiquitin to protein substrates. Defects in this gene have been associated with Fanconi anemia of complementation group T. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

Member of: DE-6 DE-6.6 Developmental clusters: GC5
Biological processes 26 terms
DNA damage response (GO:0006974)DNA damage response (GO:0006974)DNA repair (GO:0006281)chromatin binding (GO:0003682)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein K11-linked ubiquitination (GO:0070979)protein K27-linked ubiquitination (GO:0044314)protein K29-linked ubiquitination (GO:0035519)protein K48-linked ubiquitination (GO:0070936)protein K6-linked ubiquitination (GO:0085020)protein K63-linked ubiquitination (GO:0070534)protein autoubiquitination (GO:0051865)protein binding (GO:0005515)protein modification by small protein conjugation (GO:0032446)protein monoubiquitination (GO:0006513)protein polyubiquitination (GO:0000209)protein ubiquitination (GO:0016567)ubiquitin conjugating enzyme activity (GO:0061631)ubiquitin conjugating enzyme activity (GO:0061631)ubiquitin conjugating enzyme activity (GO:0061631)ubiquitin protein ligase binding (GO:0031625)ubiquitin-like protein transferase activity (GO:0019787)ubiquitin-protein transferase activity (GO:0004842)
Expression (TPM)
UBE2T — as a Regulated Gene

TFs regulating UBE2T 0 TFs

Transcription factors with Perturb-seq knockdown data for UBE2T. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE2T upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to UBE2T

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE2T, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:202,075,813–202,076,531 265.8 kb Distal (>10kb) Multiome 418
chr1:202,101,336–202,102,103 240.1 kb Distal (>10kb) Multiome 173
chr1:202,105,597–202,106,270 236.0 kb Distal (>10kb) Multiome 376
chr1:202,135,239–202,135,691 206.6 kb Distal (>10kb) Multiome 193
chr1:202,143,721–202,144,890 198.0 kb Distal (>10kb) Multiome 589
chr1:202,184,705–202,185,268 157.1 kb Distal (>10kb) Multiome 258
chr1:202,214,010–202,214,579 127.6 kb Distal (>10kb) Multiome 215
chr1:202,235,967–202,236,655 105.5 kb Distal (>10kb) Multiome 460
chr1:202,237,030–202,237,425 104.6 kb Distal (>10kb) Multiome 305
chr1:202,341,446–202,342,246 57 bp At TSS Multiome 728
chr1:202,348,195–202,349,447 6.7 kb Proximal (<10kb) Multiome 898
chr1:202,638,017–202,638,513 296.4 kb Distal (>10kb) Multiome 19
chr1:202,709,842–202,710,859 368.6 kb Distal (>10kb) Multiome HiCAR 255

Genome Browser

Genomic view of the UBE2T locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:202,065,813 – 202,720,859
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact