The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is 98% identical to the mouse counterpart. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for UBE2Q1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE2Q1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE2Q1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:154,272,082–154,272,847 | 286.2 kb | Distal (>10kb) Multiome | 834 | |
| chr1:154,324,640–154,326,731 | 233.8 kb | Distal (>10kb) Multiome | 685 | |
| chr1:154,328,267–154,328,890 | 230.1 kb | Distal (>10kb) Multiome | 261 | |
| chr1:154,352,626–154,353,487 | 205.5 kb | Distal (>10kb) Multiome | 466 | |
| chr1:154,404,987–154,406,067 | 153.2 kb | Distal (>10kb) Multiome | 731 | |
| chr1:154,489,011–154,489,730 | 69.2 kb | Distal (>10kb) Multiome HiCAR | 82 | |
| chr1:154,493,110–154,493,579 | 65.3 kb | Distal (>10kb) Multiome | 134 | |
| chr1:154,501,716–154,502,717 | 56.0 kb | Distal (>10kb) Multiome | 212 | |
| chr1:154,558,123–154,559,826 | 183 bp | At TSS Multiome | 1173 | |
| chr1:154,567,476–154,568,396 | 9.3 kb | Proximal (<10kb) Multiome | 774 | |
| chr1:154,607,914–154,609,125 | 50.0 kb | Distal (>10kb) Multiome | 720 | |
| chr1:154,627,216–154,628,267 | 69.2 kb | Distal (>10kb) Multiome | 850 | |
| chr1:154,683,607–154,684,346 | 125.4 kb | Distal (>10kb) Multiome | 39 | |
| chr1:154,760,465–154,760,941 | 202.0 kb | Distal (>10kb) Multiome | 418 | |
| chr1:154,813,354–154,814,052 | 255.0 kb | Distal (>10kb) Multiome | 189 | |
| chr1:154,870,031–154,870,680 | 311.7 kb | Distal (>10kb) Multiome HiCAR | 300 | |
| chr1:154,936,148–154,937,752 | 378.3 kb | Distal (>10kb) Multiome HiCAR | 1149 | |
| chr1:154,955,571–154,956,925 | 397.5 kb | Distal (>10kb) Multiome HiCAR | 504 |
Genomic view of the UBE2Q1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.