Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase activity. Involved in positive regulation of BMP signaling pathway; protein ubiquitination; and retrograde transport, endosome to Golgi. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UBE2O. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE2O upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE2O, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:76,240,278–76,241,169 | 212.5 kb | Distal (>10kb) Multiome | 560 | |
| chr17:76,264,834–76,266,286 | 188.0 kb | Distal (>10kb) Multiome | 868 | |
| chr17:76,353,245–76,354,535 | 99.1 kb | Distal (>10kb) Multiome | 1071 | |
| chr17:76,383,686–76,385,081 | 68.6 kb | Distal (>10kb) Multiome | 823 | |
| chr17:76,385,493–76,386,382 | 67.1 kb | Distal (>10kb) Multiome | 935 | |
| chr17:76,452,469–76,453,735 | 52 bp | At TSS Multiome | 726 | |
| chr17:76,500,907–76,502,333 | 48.3 kb | Distal (>10kb) Multiome HiCAR | 728 | |
| chr17:76,506,248–76,506,840 | 53.4 kb | Distal (>10kb) Multiome HiCAR | 550 | |
| chr17:76,537,326–76,538,627 | 84.6 kb | Distal (>10kb) Multiome | 192 | |
| chr17:76,540,451–76,541,323 | 87.8 kb | Distal (>10kb) Multiome | 478 | |
| chr17:76,557,376–76,557,942 | 104.5 kb | Distal (>10kb) Multiome | 906 | |
| chr17:76,585,404–76,586,417 | 132.8 kb | Distal (>10kb) Multiome | 591 | |
| chr17:76,612,985–76,613,550 | 160.2 kb | Distal (>10kb) Multiome | 308 | |
| chr17:76,671,049–76,672,200 | 218.6 kb | Distal (>10kb) Multiome | 947 | |
| chr17:76,708,018–76,708,518 | 255.0 kb | Distal (>10kb) Multiome | 236 | |
| chr17:76,710,928–76,711,574 | 257.9 kb | Distal (>10kb) Multiome | 421 | |
| chr17:76,725,921–76,727,506 | 273.6 kb | Distal (>10kb) Multiome | 1083 | |
| chr17:76,735,995–76,738,370 | 283.2 kb | Distal (>10kb) Multiome | 1227 |
Genomic view of the UBE2O locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.