The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for UBE2G1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE2G1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE2G1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:4,142,469–4,144,218 | 222.8 kb | Distal (>10kb) Multiome | 1007 | |
| chr17:4,263,266–4,264,359 | 102.7 kb | Distal (>10kb) Multiome | 729 | |
| chr17:4,365,147–4,367,069 | 1.3 kb | Proximal (<10kb) Multiome | 911 | |
| chr17:4,498,488–4,499,859 | 132.2 kb | Distal (>10kb) Multiome | 361 | |
| chr17:4,555,276–4,555,773 | 188.8 kb | Distal (>10kb) Multiome | 806 | |
| chr17:4,583,931–4,585,086 | 217.7 kb | Distal (>10kb) Multiome | 323 |
Genomic view of the UBE2G1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.