The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for UBE2C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE2C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE2C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:45,764,655–45,765,666 | 47.5 kb | Distal (>10kb) Multiome | 192 | |
| chr20:45,770,709–45,771,657 | 41.4 kb | Distal (>10kb) Multiome | 436 | |
| chr20:45,791,633–45,792,259 | 20.7 kb | Distal (>10kb) Multiome | 882 | |
| chr20:45,812,087–45,813,052 | 165 bp | At TSS Multiome | 695 | |
| chr20:45,833,493–45,834,622 | 21.3 kb | Distal (>10kb) Multiome | 833 | |
| chr20:45,856,871–45,858,137 | 44.9 kb | Distal (>10kb) Multiome | 884 | |
| chr20:45,880,796–45,881,524 | 68.5 kb | Distal (>10kb) Multiome | 738 | |
| chr20:45,890,127–45,891,800 | 78.7 kb | Distal (>10kb) Multiome | 1095 | |
| chr20:45,910,538–45,912,397 | 99.6 kb | Distal (>10kb) Multiome | 713 | |
| chr20:45,933,591–45,935,780 | 122.5 kb | Distal (>10kb) Multiome | 1195 | |
| chr20:45,971,553–45,972,790 | 159.5 kb | Distal (>10kb) Multiome | 1206 | |
| chr20:46,004,647–46,005,315 | 192.3 kb | Distal (>10kb) Multiome | 207 | |
| chr20:46,011,604–46,012,166 | 199.3 kb | Distal (>10kb) Multiome | 239 | |
| chr20:46,013,565–46,014,586 | 201.5 kb | Distal (>10kb) Multiome | 735 | |
| chr20:46,021,209–46,023,166 | 209.4 kb | Distal (>10kb) Multiome | 679 | |
| chr20:46,031,750–46,032,261 | 219.4 kb | Distal (>10kb) Multiome | 227 | |
| chr20:46,058,408–46,058,983 | 246.2 kb | Distal (>10kb) Multiome | 123 | |
| chr20:46,089,092–46,090,355 | 277.2 kb | Distal (>10kb) Multiome | 1047 | |
| chr20:46,091,736–46,092,300 | 279.6 kb | Distal (>10kb) Multiome | 38 |
Genomic view of the UBE2C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.