The protein encoded by this gene contains a UBA (ubiquitin associated) domain, which is characteristic of proteins that function in the ubiquitination pathway. This gene may show increased expression in the adrenal gland and lymphatic tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for UBAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:33,816,538–33,818,390 | 231.0 kb | Distal (>10kb) Multiome | 924 | |
| chr9:34,048,315–34,049,845 | 21 bp | At TSS Multiome | 1045 | |
| chr9:34,049,943–34,050,924 | 1.3 kb | Proximal (<10kb) Multiome | 283 | |
| chr9:34,126,146–34,127,302 | 77.5 kb | Distal (>10kb) Multiome | 826 | |
| chr9:34,178,460–34,179,845 | 129.9 kb | Distal (>10kb) Multiome | 814 | |
| chr9:34,328,711–34,329,961 | 280.2 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the UBAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.