Predicted to enable ubiquitin binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be part of ESCRT I complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UBAP1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBAP1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBAP1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:64,807,123–64,808,403 | 293.7 kb | Distal (>10kb) Multiome | 248 | |
| chr15:64,808,791–64,809,297 | 292.5 kb | Distal (>10kb) Multiome | 89 | |
| chr15:64,809,806–64,810,371 | 291.5 kb | Distal (>10kb) Multiome | 298 | |
| chr15:64,823,825–64,824,470 | 277.5 kb | Distal (>10kb) Multiome | 206 | |
| chr15:64,825,130–64,826,273 | 275.8 kb | Distal (>10kb) Multiome | 784 | |
| chr15:64,840,757–64,843,201 | 260.0 kb | Distal (>10kb) Multiome | 732 | |
| chr15:64,893,790–64,894,635 | 207.5 kb | Distal (>10kb) Multiome | 506 | |
| chr15:64,905,276–64,905,958 | 196.0 kb | Distal (>10kb) Multiome | 362 | |
| chr15:64,911,481–64,912,188 | 189.8 kb | Distal (>10kb) Multiome | 308 | |
| chr15:64,915,576–64,916,281 | 185.7 kb | Distal (>10kb) Multiome | 115 | |
| chr15:64,989,345–64,990,371 | 111.7 kb | Distal (>10kb) Multiome | 859 | |
| chr15:65,028,915–65,029,974 | 72.1 kb | Distal (>10kb) Multiome HiCAR | 703 | |
| chr15:65,049,359–65,049,794 | 52.1 kb | Distal (>10kb) Multiome | 267 | |
| chr15:65,067,081–65,068,384 | 33.5 kb | Distal (>10kb) Multiome | 131 | |
| chr15:65,101,638–65,102,425 | 282 bp | At TSS Multiome | 204 | |
| chr15:65,132,889–65,133,960 | 32.1 kb | Distal (>10kb) Multiome | 775 | |
| chr15:65,184,434–65,185,938 | 83.8 kb | Distal (>10kb) Multiome | 985 | |
| chr15:65,286,029–65,287,330 | 185.3 kb | Distal (>10kb) Multiome | 919 | |
| chr15:65,295,595–65,297,682 | 194.6 kb | Distal (>10kb) Multiome | 1039 | |
| chr15:65,299,879–65,301,676 | 199.4 kb | Distal (>10kb) Multiome | 464 | |
| chr15:65,303,709–65,305,825 | 203.2 kb | Distal (>10kb) Multiome | 1230 | |
| chr15:65,355,116–65,356,095 | 254.0 kb | Distal (>10kb) Multiome | 288 | |
| chr15:65,376,859–65,378,657 | 276.4 kb | Distal (>10kb) Multiome | 612 | |
| chr15:65,384,869–65,386,083 | 284.1 kb | Distal (>10kb) Multiome | 703 | |
| chr15:65,400,812–65,401,824 | 299.8 kb | Distal (>10kb) Multiome | 406 |
Genomic view of the UBAP1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.