Enables identical protein binding activity and protein serine pyrophosphorylase activity. Involved in antiviral innate immune response and positive regulation of type I interferon production. Located in nucleoplasm and plasma membrane. Is active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:162,069,229–162,071,225 | 492.0 kb | Distal (>10kb) Multiome HiCAR | 662 | |
| chr1:162,391,686–162,392,380 | 169.7 kb | Distal (>10kb) Multiome | 276 | |
| chr1:162,443,805–162,444,309 | 117.7 kb | Distal (>10kb) Multiome | 88 | |
| chr1:162,464,538–162,465,124 | 97.0 kb | Distal (>10kb) Multiome | 39 | |
| chr1:162,497,482–162,498,431 | 63.8 kb | Distal (>10kb) Multiome | 778 | |
| chr1:162,560,729–162,562,552 | 225 bp | At TSS Multiome | 1005 | |
| chr1:162,696,268–162,696,983 | 134.9 kb | Distal (>10kb) Multiome | 473 | |
| chr1:162,822,352–162,823,207 | 261.1 kb | Distal (>10kb) Multiome | 350 |
Genomic view of the UAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.