Enables disulfide oxidoreductase activity. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TXNL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TXNL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TXNL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:55,322,133–55,322,873 | 1329.2 kb | Distal (>10kb) Multiome HiCAR | 382 | |
| chr18:55,572,972–55,573,887 | 1078.0 kb | Distal (>10kb) Multiome HiCAR | 122 | |
| chr18:56,637,964–56,639,090 | 12.9 kb | Distal (>10kb) Multiome | 800 | |
| chr18:56,647,924–56,648,674 | 3.2 kb | Proximal (<10kb) Multiome | 57 | |
| chr18:56,650,881–56,651,893 | 262 bp | At TSS Multiome | 834 | |
| chr18:56,913,889–56,914,807 | 262.7 kb | Distal (>10kb) Multiome | 134 |
Genomic view of the TXNL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.