This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for TXNDC12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TXNDC12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TXNDC12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:51,877,934–51,879,493 | 176.3 kb | Distal (>10kb) Multiome | 1012 | |
| chr1:51,957,425–51,958,172 | 97.4 kb | Distal (>10kb) Multiome | 194 | |
| chr1:51,960,124–51,960,875 | 94.7 kb | Distal (>10kb) Multiome | 141 | |
| chr1:51,989,938–51,991,038 | 64.5 kb | Distal (>10kb) Multiome | 410 | |
| chr1:52,032,841–52,033,969 | 21.5 kb | Distal (>10kb) Multiome | 829 | |
| chr1:52,054,893–52,057,012 | 1.2 kb | Proximal (<10kb) Multiome | 1080 | |
| chr1:52,141,669–52,142,926 | 86.9 kb | Distal (>10kb) Multiome | 839 | |
| chr1:52,240,504–52,241,012 | 185.6 kb | Distal (>10kb) Multiome | 110 |
Genomic view of the TXNDC12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.