Predicted to enable syntaxin binding activity. Predicted to be involved in exocytosis. Predicted to act upstream of or within B cell activation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TXLNA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TXLNA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TXLNA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:31,937,587–31,938,944 | 241.6 kb | Distal (>10kb) Multiome | 1111 | |
| chr1:31,943,994–31,945,090 | 235.5 kb | Distal (>10kb) Multiome | 826 | |
| chr1:31,954,721–31,955,545 | 224.9 kb | Distal (>10kb) Multiome | 628 | |
| chr1:31,964,141–31,964,595 | 215.8 kb | Distal (>10kb) Multiome | 529 | |
| chr1:32,013,168–32,015,085 | 166.4 kb | Distal (>10kb) Multiome | 988 | |
| chr1:32,072,319–32,073,738 | 106.9 kb | Distal (>10kb) Multiome | 909 | |
| chr1:32,107,881–32,108,706 | 72.0 kb | Distal (>10kb) Multiome | 779 | |
| chr1:32,179,263–32,180,190 | 292 bp | At TSS Multiome | 1019 | |
| chr1:32,180,386–32,180,609 | 712 bp | At TSS | 321 | |
| chr1:32,200,233–32,201,756 | 20.6 kb | Distal (>10kb) Multiome | 573 | |
| chr1:32,204,985–32,206,258 | 25.5 kb | Distal (>10kb) Multiome | 679 | |
| chr1:32,221,877–32,222,889 | 42.3 kb | Distal (>10kb) Multiome | 755 | |
| chr1:32,239,728–32,240,979 | 60.3 kb | Distal (>10kb) Multiome | 456 | |
| chr1:32,248,081–32,248,895 | 68.4 kb | Distal (>10kb) Multiome | 622 | |
| chr1:32,291,710–32,292,726 | 112.0 kb | Distal (>10kb) Multiome | 900 | |
| chr1:32,334,713–32,336,836 | 156.2 kb | Distal (>10kb) Multiome | 804 | |
| chr1:32,351,055–32,352,355 | 171.4 kb | Distal (>10kb) Multiome | 944 | |
| chr1:32,361,365–32,362,459 | 182.1 kb | Distal (>10kb) Multiome | 305 | |
| chr1:32,393,928–32,395,356 | 214.5 kb | Distal (>10kb) Multiome | 930 | |
| chr1:32,437,702–32,438,502 | 258.2 kb | Distal (>10kb) Multiome | 85 | |
| chr1:32,439,697–32,440,223 | 259.8 kb | Distal (>10kb) Multiome | 40 | |
| chr1:32,464,697–32,465,552 | 285.0 kb | Distal (>10kb) Multiome | 408 |
Genomic view of the TXLNA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.