TUT1
terminal uridylyl transferase 1, U6 snRNA-specific | FLJ21850, FLJ22267, FLJ22347, PAPD2, TENT1, TUTase, RBM21

This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation.[provided by RefSeq, Apr 2009]

Biological processes 32 terms
RNA 3'-end processing (GO:0031123)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA uridylyltransferase activity (GO:0050265)RNA uridylyltransferase activity (GO:0050265)RNA uridylyltransferase activity (GO:0050265)U6 snRNA 3'-end processing (GO:0034477)U6 snRNA binding (GO:0017070)co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway (GO:0180010)co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway (GO:0180010)enzyme binding (GO:0019899)enzyme-substrate adaptor activity (GO:0140767)histone mRNA catabolic process (GO:0071044)mRNA 3'-UTR binding (GO:0003730)mRNA 3'-end processing (GO:0031124)mRNA cleavage and polyadenylation specificity factor complex (GO:0005847)nuclear speck (GO:0016607)nuclear speck (GO:0016607)nuclear speck (GO:0016607)nucleic acid binding (GO:0003676)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)poly(A) RNA polymerase activity (GO:1990817)poly(A) RNA polymerase activity (GO:1990817)poly(A) RNA polymerase activity (GO:1990817)polyuridylation-dependent mRNA catabolic process (GO:1990074)protein binding (GO:0005515)regulation of RNA metabolic process (GO:0051252)snRNA processing (GO:0016180)
Expression (TPM)
TUT1 — as a Regulated Gene

TFs regulating TUT1 0 TFs

Transcription factors with Perturb-seq knockdown data for TUT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TUT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TUT1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TUT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr11:62,337,140–62,338,142 254.0 kb Distal (>10kb) Multiome 611
chr11:62,382,190–62,383,008 208.9 kb Distal (>10kb) Multiome HiCAR 36
chr11:62,460,403–62,461,004 130.8 kb Distal (>10kb) Multiome 20
chr11:62,508,289–62,508,878 83.0 kb Distal (>10kb) Multiome 499
chr11:62,542,658–62,543,488 48.5 kb Distal (>10kb) Multiome 537
chr11:62,545,051–62,547,562 44.5 kb Distal (>10kb) Multiome 889
chr11:62,553,213–62,553,741 38.1 kb Distal (>10kb) Multiome 489
chr11:62,555,905–62,556,742 35.2 kb Distal (>10kb) Multiome 545
chr11:62,560,588–62,561,104 30.8 kb Distal (>10kb) Multiome 541
chr11:62,561,760–62,562,358 29.5 kb Distal (>10kb) Multiome 43
chr11:62,573,347–62,574,645 17.5 kb Distal (>10kb) Multiome 845
chr11:62,591,246–62,592,462 225 bp At TSS Multiome 976
chr11:62,593,640–62,593,821 2.1 kb Proximal (<10kb) 261
chr11:62,599,145–62,599,532 7.6 kb Proximal (<10kb) 580
chr11:62,600,988–62,603,291 10.4 kb Distal (>10kb) Multiome 872
chr11:62,611,665–62,613,544 21.4 kb Distal (>10kb) Multiome 737
chr11:62,621,550–62,622,445 30.5 kb Distal (>10kb) Multiome 964
chr11:62,646,025–62,647,031 55.1 kb Distal (>10kb) Multiome 815
chr11:62,652,836–62,653,744 61.8 kb Distal (>10kb) Multiome 921
chr11:62,664,567–62,666,291 73.7 kb Distal (>10kb) Multiome 1020
chr11:62,671,328–62,672,522 80.2 kb Distal (>10kb) Multiome 882
chr11:62,705,543–62,707,930 114.8 kb Distal (>10kb) Multiome 760
chr11:62,708,691–62,710,293 118.1 kb Distal (>10kb) Multiome 531
chr11:62,726,557–62,728,947 136.1 kb Distal (>10kb) Multiome 1088
chr11:62,753,347–62,754,665 162.6 kb Distal (>10kb) Multiome 696
chr11:62,761,085–62,762,045 170.0 kb Distal (>10kb) Multiome 649
chr11:62,770,753–62,772,068 179.9 kb Distal (>10kb) Multiome 885
chr11:62,786,365–62,787,860 195.0 kb Distal (>10kb) Multiome 1073
chr11:62,791,569–62,792,385 200.5 kb Distal (>10kb) Multiome 805
chr11:62,804,451–62,807,080 214.0 kb Distal (>10kb) Multiome 994
chr11:62,831,037–62,832,904 240.5 kb Distal (>10kb) Multiome 870
chr11:62,839,042–62,842,743 249.9 kb Distal (>10kb) Multiome 1403
chr11:62,851,028–62,851,955 260.0 kb Distal (>10kb) Multiome 421
chr11:62,855,209–62,856,560 264.5 kb Distal (>10kb) Multiome 1071
chr11:62,862,252–62,862,948 271.2 kb Distal (>10kb) Multiome 360
chr11:62,880,343–62,881,977 289.4 kb Distal (>10kb) Multiome 1080

Genome Browser

Genomic view of the TUT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr11:62,327,140 – 62,891,977
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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