TUBB2B

tubulin beta 2B class IIb | DKFZp566F223, MGC8685, bA506K6.1

The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]

Member of: DE-1 DE-1.17 Developmental clusters: GC3

Biological processes 29 terms

GTP binding (GO:0005525)GTP binding (GO:0005525)GTPase activity (GO:0003924)ciliary tip (GO:0097542)cilium (GO:0005929)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)intercellular bridge (GO:0045171)intercellular bridge (GO:0045171)microtubule (GO:0005874)microtubule (GO:0005874)microtubule (GO:0005874)microtubule cytoskeleton (GO:0015630)microtubule cytoskeleton organization (GO:0000226)microtubule-based process (GO:0007017)microtubule-based process (GO:0007017)mitotic cell cycle (GO:0000278)mitotic spindle (GO:0072686)mitotic spindle (GO:0072686)neuron migration (GO:0001764)neuron migration (GO:0001764)nucleus (GO:0005634)positive regulation of axon guidance (GO:1902669)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)sperm end piece (GO:0097229)sperm principal piece (GO:0097228)structural constituent of cytoskeleton (GO:0005200)structural constituent of cytoskeleton (GO:0005200)

Expression (TPM)

TFs regulating TUBB2B 0 TFs

Transcription factors with Perturb-seq knockdown data for TUBB2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TUBB2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TUBB2B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TUBB2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:2,927,704–2,929,196	299.4 kb	Distal (>10kb) Multiome	154
chr6:2,931,916–2,932,749	295.3 kb	Distal (>10kb) Multiome	652
chr6:2,942,573–2,943,965	284.6 kb	Distal (>10kb) Multiome	222
chr6:2,952,443–2,953,210	274.8 kb	Distal (>10kb) Multiome	649
chr6:2,970,836–2,972,016	256.3 kb	Distal (>10kb) Multiome	817
chr6:2,985,539–2,987,671	241.6 kb	Distal (>10kb) Multiome	402
chr6:2,987,802–2,990,098	237.8 kb	Distal (>10kb) Multiome	1173
chr6:2,990,284–2,991,348	236.7 kb	Distal (>10kb) Multiome	509
chr6:2,999,131–3,000,475	227.9 kb	Distal (>10kb) Multiome	930
chr6:3,041,670–3,042,232	185.7 kb	Distal (>10kb) Multiome	84
chr6:3,052,936–3,054,463	173.9 kb	Distal (>10kb) Multiome	864
chr6:3,063,662–3,064,609	163.7 kb	Distal (>10kb) Multiome	752
chr6:3,068,179–3,069,296	158.9 kb	Distal (>10kb) Multiome	1032
chr6:3,118,061–3,119,380	109.0 kb	Distal (>10kb) Multiome HiCAR	966
chr6:3,156,701–3,158,249	70.0 kb	Distal (>10kb) Multiome HiCAR	859
chr6:3,162,506–3,163,526	64.7 kb	Distal (>10kb) Multiome HiCAR	926
chr6:3,165,678–3,166,637	61.3 kb	Distal (>10kb) Multiome HiCAR	343
chr6:3,226,566–3,229,919	120 bp	At TSS Multiome	770
chr6:3,231,202–3,232,265	4.1 kb	Proximal (<10kb) Multiome HiCAR	593
chr6:3,251,328–3,252,273	24.1 kb	Distal (>10kb) Multiome	561
chr6:3,258,552–3,259,886	31.3 kb	Distal (>10kb) Multiome	946
chr6:3,356,075–3,356,744	128.7 kb	Distal (>10kb) Multiome	475
chr6:3,414,872–3,415,397	187.5 kb	Distal (>10kb) Multiome	265
chr6:3,423,549–3,424,168	196.2 kb	Distal (>10kb) Multiome	107
chr6:3,455,491–3,458,021	229.4 kb	Distal (>10kb) Multiome	809
chr6:3,511,478–3,512,074	284.0 kb	Distal (>10kb) Multiome	323

Genome Browser

Genomic view of the TUBB2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.