This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TUB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TUB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TUB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:7,986,569–7,987,645 | 32.0 kb | Distal (>10kb) Multiome | 879 | |
| chr11:8,015,683–8,015,934 | 3.3 kb | Proximal (<10kb) | 10 | |
| chr11:8,016,443–8,016,699 | 2.5 kb | Proximal (<10kb) | 63 | |
| chr11:8,018,776–8,020,008 | 3 bp | At TSS Multiome HiCAR | 365 | |
| chr11:8,032,871–8,033,670 | 14.1 kb | Distal (>10kb) Multiome HiCAR | 307 | |
| chr11:8,072,205–8,072,596 | 8.6 kb | Proximal (<10kb) | 43 | |
| chr11:8,080,656–8,082,014 | 62.0 kb | Distal (>10kb) Multiome HiCAR | 370 | |
| chr11:8,087,281–8,087,513 | 6.1 kb | Proximal (<10kb) | 30 | |
| chr11:8,090,824–8,091,054 | 9.6 kb | Proximal (<10kb) | 65 | |
| chr11:8,168,430–8,169,450 | 149.7 kb | Distal (>10kb) Multiome | 329 | |
| chr11:8,192,451–8,193,309 | 173.6 kb | Distal (>10kb) Multiome | 185 | |
| chr11:8,261,997–8,263,550 | 243.6 kb | Distal (>10kb) Multiome | 309 | |
| chr11:8,267,870–8,269,102 | 249.3 kb | Distal (>10kb) Multiome | 247 | |
| chr11:8,328,690–8,329,408 | 309.8 kb | Distal (>10kb) Multiome | 403 |
Genomic view of the TUB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.