This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TTYH3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTYH3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTYH3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:2,353,760–2,355,437 | 277.3 kb | Distal (>10kb) Multiome | 1060 | |
| chr7:2,403,048–2,404,583 | 228.5 kb | Distal (>10kb) Multiome | 775 | |
| chr7:2,451,319–2,452,043 | 180.4 kb | Distal (>10kb) Multiome | 660 | |
| chr7:2,518,679–2,520,557 | 112.3 kb | Distal (>10kb) Multiome | 567 | |
| chr7:2,555,131–2,556,097 | 76.2 kb | Distal (>10kb) Multiome | 772 | |
| chr7:2,558,641–2,559,572 | 73.0 kb | Distal (>10kb) Multiome | 669 | |
| chr7:2,631,170–2,632,859 | 201 bp | At TSS Multiome | 658 | |
| chr7:2,633,014–2,634,223 | 1.0 kb | Proximal (<10kb) | 498 | |
| chr7:2,646,545–2,647,390 | 15.1 kb | Distal (>10kb) Multiome | 245 | |
| chr7:2,688,023–2,688,723 | 56.3 kb | Distal (>10kb) Multiome | 176 | |
| chr7:2,706,487–2,707,069 | 74.9 kb | Distal (>10kb) Multiome | 81 | |
| chr7:2,709,414–2,710,178 | 77.9 kb | Distal (>10kb) Multiome | 481 | |
| chr7:2,821,232–2,821,746 | 189.6 kb | Distal (>10kb) Multiome | 210 | |
| chr7:2,843,825–2,845,052 | 212.5 kb | Distal (>10kb) Multiome | 635 |
Genomic view of the TTYH3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.