This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for TTYH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTYH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTYH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:54,136,562–54,138,683 | 283.3 kb | Distal (>10kb) Multiome | 751 | |
| chr19:54,159,030–54,160,865 | 260.8 kb | Distal (>10kb) Multiome | 793 | |
| chr19:54,161,897–54,162,738 | 258.3 kb | Distal (>10kb) Multiome | 233 | |
| chr19:54,164,508–54,165,013 | 255.9 kb | Distal (>10kb) Multiome | 183 | |
| chr19:54,172,536–54,173,532 | 247.5 kb | Distal (>10kb) Multiome | 397 | |
| chr19:54,188,192–54,192,172 | 229.9 kb | Distal (>10kb) Multiome | 979 | |
| chr19:54,200,383–54,201,351 | 219.9 kb | Distal (>10kb) Multiome | 891 | |
| chr19:54,208,780–54,209,556 | 211.3 kb | Distal (>10kb) Multiome | 358 | |
| chr19:54,231,547–54,232,136 | 188.8 kb | Distal (>10kb) Multiome | 471 | |
| chr19:54,420,287–54,421,161 | 178 bp | At TSS Multiome | 334 | |
| chr19:54,430,381–54,431,285 | 10.3 kb | Distal (>10kb) Multiome | 240 | |
| chr19:54,439,510–54,439,707 | 8.7 kb | Proximal (<10kb) | 142 | |
| chr19:54,448,346–54,449,853 | 28.5 kb | Distal (>10kb) Multiome | 959 | |
| chr19:54,462,469–54,465,494 | 43.3 kb | Distal (>10kb) Multiome | 1004 |
Genomic view of the TTYH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.