Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to act upstream of or within regulation of blastocyst development. Predicted to be located in cytosol. Predicted to be active in ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TTLL4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTLL4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTLL4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:218,567,787–218,569,400 | 142.4 kb | Distal (>10kb) Multiome | 1083 | |
| chr2:218,658,668–218,660,011 | 51.3 kb | Distal (>10kb) Multiome | 870 | |
| chr2:218,671,689–218,672,558 | 38.8 kb | Distal (>10kb) Multiome | 794 | |
| chr2:218,710,272–218,711,420 | 41 bp | At TSS Multiome | 957 | |
| chr2:218,781,682–218,782,718 | 71.2 kb | Distal (>10kb) Multiome | 674 | |
| chr2:218,798,810–218,799,640 | 88.3 kb | Distal (>10kb) Multiome | 163 | |
| chr2:218,799,866–218,800,388 | 89.5 kb | Distal (>10kb) Multiome | 82 | |
| chr2:218,860,491–218,861,382 | 150.2 kb | Distal (>10kb) Multiome | 241 | |
| chr2:218,883,560–218,884,239 | 173.0 kb | Distal (>10kb) Multiome | 190 | |
| chr2:218,892,714–218,893,400 | 182.0 kb | Distal (>10kb) Multiome | 591 | |
| chr2:218,898,077–218,898,730 | 187.5 kb | Distal (>10kb) Multiome | 624 | |
| chr2:218,908,757–218,909,543 | 198.3 kb | Distal (>10kb) Multiome | 885 | |
| chr2:218,959,145–218,960,352 | 248.7 kb | Distal (>10kb) Multiome | 416 | |
| chr2:218,962,902–218,964,278 | 252.4 kb | Distal (>10kb) Multiome | 768 | |
| chr2:218,979,814–218,980,492 | 269.2 kb | Distal (>10kb) Multiome | 499 | |
| chr2:218,984,382–218,985,013 | 273.7 kb | Distal (>10kb) Multiome | 126 | |
| chr2:218,992,930–218,994,312 | 282.7 kb | Distal (>10kb) Multiome | 265 | |
| chr2:218,995,885–218,998,018 | 285.3 kb | Distal (>10kb) Multiome | 534 | |
| chr2:218,998,611–219,003,562 | 291.2 kb | Distal (>10kb) Multiome | 941 |
Genomic view of the TTLL4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.