This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for TTK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:79,777,822–79,779,056 | 226.4 kb | Distal (>10kb) Multiome | 471 | |
| chr6:79,869,214–79,870,099 | 134.9 kb | Distal (>10kb) Multiome | 584 | |
| chr6:79,946,362–79,948,249 | 57.0 kb | Distal (>10kb) Multiome | 553 | |
| chr6:80,003,546–80,005,540 | 57 bp | At TSS Multiome | 751 | |
| chr6:80,105,995–80,107,273 | 102.0 kb | Distal (>10kb) Multiome | 842 | |
| chr6:80,162,998–80,164,431 | 159.3 kb | Distal (>10kb) Multiome | 331 |
Genomic view of the TTK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.