This gene encodes a protein containing tetratricopeptide repeats. Mutations in this gene disrupt intestinal development and can cause early onset inflammatory bowel disease and intestinal atresia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for TTC7A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTC7A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTC7A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:46,616,071–46,617,512 | 298.8 kb | Distal (>10kb) Multiome | 955 | |
| chr2:46,698,279–46,700,093 | 216.9 kb | Distal (>10kb) Multiome | 974 | |
| chr2:46,704,551–46,705,027 | 211.1 kb | Distal (>10kb) Multiome | 109 | |
| chr2:46,915,163–46,916,556 | 32 bp | At TSS Multiome | 931 | |
| chr2:46,940,391–46,942,183 | 25.4 kb | Distal (>10kb) Multiome | 931 | |
| chr2:46,986,672–46,987,498 | 71.3 kb | Distal (>10kb) Multiome | 630 | |
| chr2:47,019,690–47,020,313 | 104.2 kb | Distal (>10kb) Multiome | 52 | |
| chr2:47,174,954–47,177,223 | 260.9 kb | Distal (>10kb) Multiome | 1239 | |
| chr2:47,309,704–47,310,671 | 394.2 kb | Distal (>10kb) Multiome HiCAR | 599 |
Genomic view of the TTC7A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.