This gene encodes a protein that belongs to the tetratrico peptide repeat superfamily of proteins. The encoded protein plays a role in protein-protein interactions, and binds to the Galpha subunit of G protein-coupled receptors to activate the Ras signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for TTC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:159,262,736–159,263,791 | 745.9 kb | Distal (>10kb) Multiome HiCAR | 849 | |
| chr5:159,442,094–159,442,787 | 566.6 kb | Distal (>10kb) Multiome HiCAR | 60 | |
| chr5:159,773,040–159,775,037 | 235.8 kb | Distal (>10kb) Multiome | 642 | |
| chr5:159,915,806–159,917,141 | 92.7 kb | Distal (>10kb) Multiome | 380 | |
| chr5:159,971,757–159,973,420 | 37.0 kb | Distal (>10kb) Multiome | 189 | |
| chr5:159,986,837–159,987,682 | 21.7 kb | Distal (>10kb) Multiome | 416 | |
| chr5:160,008,719–160,009,383 | 72 bp | At TSS Multiome | 737 | |
| chr5:160,118,295–160,120,363 | 110.5 kb | Distal (>10kb) Multiome | 890 | |
| chr5:160,133,074–160,134,351 | 124.4 kb | Distal (>10kb) Multiome | 270 | |
| chr5:160,159,956–160,160,873 | 151.1 kb | Distal (>10kb) Multiome | 276 | |
| chr5:160,161,037–160,162,516 | 152.8 kb | Distal (>10kb) Multiome | 167 | |
| chr5:160,165,122–160,166,166 | 156.7 kb | Distal (>10kb) Multiome | 537 | |
| chr5:160,188,095–160,189,161 | 179.4 kb | Distal (>10kb) Multiome | 472 | |
| chr5:160,199,034–160,200,016 | 190.4 kb | Distal (>10kb) Multiome | 455 | |
| chr5:160,287,012–160,288,061 | 278.5 kb | Distal (>10kb) Multiome | 461 | |
| chr5:160,399,366–160,400,211 | 390.8 kb | Distal (>10kb) Multiome HiCAR | 808 |
Genomic view of the TTC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.