This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for TSHZ3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSHZ3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSHZ3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:29,665,021–29,667,200 | 1684.1 kb | Distal (>10kb) Multiome HiCAR | 621 | |
| chr19:31,258,193–31,259,001 | 90.8 kb | Distal (>10kb) Multiome | 73 | |
| chr19:31,348,590–31,352,149 | 121 bp | At TSS Multiome | 483 | |
| chr19:31,353,950–31,354,273 | 4.5 kb | Proximal (<10kb) | 44 | |
| chr19:31,355,448–31,355,593 | 6.0 kb | Proximal (<10kb) | 43 | |
| chr19:31,357,011–31,357,345 | 7.6 kb | Proximal (<10kb) | 191 | |
| chr19:31,424,401–31,425,424 | 75.5 kb | Distal (>10kb) Multiome | 195 | |
| chr19:31,518,401–31,519,583 | 169.6 kb | Distal (>10kb) Multiome | 145 | |
| chr19:32,345,298–32,346,342 | 996.2 kb | Distal (>10kb) Multiome HiCAR | 791 |
Genomic view of the TSHZ3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.