TSC22D4

TSC22 domain family member 4 | THG-1, TILZ2

TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators (see TSC22D3; MIM 300506) (Kester et al., 1999 [PubMed 10488076]; Fiorenza et al., 2001 [PubMed 11707329]).[supplied by OMIM, Mar 2008]

Developmental clusters: GC6

Biological processes 20 terms

cytoplasm (GO:0005737)cytoplasm (GO:0005737)dendrite (GO:0030425)dendrite (GO:0030425)glucose homeostasis (GO:0042593)glucose homeostasis (GO:0042593)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)neuron cellular homeostasis (GO:0070050)neuron cellular homeostasis (GO:0070050)neuron projection extension (GO:1990138)neuron projection extension (GO:1990138)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)response to osmotic stress (GO:0006970)synapse (GO:0045202)synapse (GO:0045202)

Expression (TPM)

TFs regulating TSC22D4 0 TFs

Transcription factors with Perturb-seq knockdown data for TSC22D4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSC22D4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TSC22D4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSC22D4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:100,266,531–100,267,045	212.5 kb	Distal (>10kb) Multiome	24
chr7:100,270,225–100,270,813	208.6 kb	Distal (>10kb) Multiome	103
chr7:100,271,732–100,272,774	206.9 kb	Distal (>10kb) Multiome	530
chr7:100,335,652–100,336,470	143.1 kb	Distal (>10kb) Multiome	706
chr7:100,381,682–100,382,670	97.2 kb	Distal (>10kb) Multiome	49
chr7:100,428,059–100,431,175	50.3 kb	Distal (>10kb) Multiome	1296
chr7:100,435,379–100,436,927	42.7 kb	Distal (>10kb) Multiome	931
chr7:100,450,379–100,450,973	28.5 kb	Distal (>10kb) Multiome	785
chr7:100,469,319–100,469,674	9.6 kb	Proximal (<10kb)	412
chr7:100,478,582–100,479,753	160 bp	At TSS Multiome	842
chr7:100,482,937–100,484,533	4.4 kb	Proximal (<10kb) Multiome	677
chr7:100,538,557–100,539,759	59.8 kb	Distal (>10kb) Multiome	858
chr7:100,542,221–100,542,986	63.5 kb	Distal (>10kb) Multiome HiCAR	274
chr7:100,569,177–100,570,642	90.4 kb	Distal (>10kb) Multiome HiCAR	855
chr7:100,585,161–100,587,241	107.2 kb	Distal (>10kb) Multiome HiCAR	966
chr7:100,611,685–100,612,981	133.0 kb	Distal (>10kb) Multiome	767
chr7:100,626,427–100,627,057	147.5 kb	Distal (>10kb) Multiome	415
chr7:100,656,111–100,656,626	177.2 kb	Distal (>10kb) Multiome	653
chr7:100,673,043–100,674,892	194.3 kb	Distal (>10kb) Multiome	934
chr7:100,674,996–100,676,406	196.7 kb	Distal (>10kb) Multiome	439
chr7:100,691,570–100,692,163	212.6 kb	Distal (>10kb) Multiome	364
chr7:100,693,475–100,694,667	215.1 kb	Distal (>10kb) Multiome	607
chr7:100,705,140–100,706,426	226.7 kb	Distal (>10kb) Multiome	962

Genome Browser

Genomic view of the TSC22D4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.