TRPM4
transient receptor potential cation channel subfamily M member 4 | FLJ20041

The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016]

Biological processes 57 terms
ATP binding (GO:0005524)Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)calcium channel activity (GO:0005262)calcium ion binding (GO:0005509)calcium ion transmembrane transport (GO:0070588)calcium ion transmembrane transport (GO:0070588)calcium-activated cation channel activity (GO:0005227)calcium-activated cation channel activity (GO:0005227)calcium-activated cation channel activity (GO:0005227)calcium-activated cation channel activity (GO:0005227)calcium-mediated signaling (GO:0019722)cellular response to ATP (GO:0071318)dendritic cell chemotaxis (GO:0002407)dendritic cell chemotaxis (GO:0002407)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)identical protein binding (GO:0042802)membrane (GO:0016020)membrane (GO:0016020)membrane depolarization during AV node cell action potential (GO:0086045)membrane depolarization during Purkinje myocyte cell action potential (GO:0086047)membrane depolarization during bundle of His cell action potential (GO:0086048)metal ion transmembrane transporter activity (GO:0046873)metal ion transport (GO:0030001)monoatomic cation transmembrane transport (GO:0098655)monoatomic ion channel activity (GO:0005216)monoatomic ion transport (GO:0006811)negative regulation of bone mineralization (GO:0030502)negative regulation of osteoblast differentiation (GO:0045668)neuronal cell body (GO:0043025)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of adipose tissue development (GO:1904179)positive regulation of atrial cardiac muscle cell action potential (GO:1903949)positive regulation of canonical Wnt signaling pathway (GO:0090263)positive regulation of cell population proliferation (GO:0008284)positive regulation of cytosolic calcium ion concentration (GO:0007204)positive regulation of fat cell differentiation (GO:0045600)positive regulation of heart rate (GO:0010460)positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0035774)positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization (GO:1904199)positive regulation of vasoconstriction (GO:0045907)protein binding (GO:0005515)protein homotetramerization (GO:0051289)protein homotetramerization (GO:0051289)protein sumoylation (GO:0016925)regulation of T cell cytokine production (GO:0002724)regulation of heart rate by cardiac conduction (GO:0086091)regulation of ventricular cardiac muscle cell action potential (GO:0098911)sodium channel activity (GO:0005272)sodium channel complex (GO:0034706)sodium ion import across plasma membrane (GO:0098719)transmembrane transport (GO:0055085)transmembrane transport (GO:0055085)
Expression (TPM)
TRPM4 — as a Regulated Gene

TFs regulating TRPM4 0 TFs

Transcription factors with Perturb-seq knockdown data for TRPM4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRPM4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TRPM4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRPM4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:48,872,000–48,873,835 285.4 kb Distal (>10kb) Multiome 987
chr19:48,895,958–48,896,628 261.5 kb Distal (>10kb) Multiome 207
chr19:48,899,782–48,900,620 257.5 kb Distal (>10kb) Multiome 710
chr19:48,933,397–48,933,948 224.1 kb Distal (>10kb) Multiome 458
chr19:48,954,440–48,955,356 202.9 kb Distal (>10kb) Multiome 905
chr19:48,963,322–48,964,187 194.0 kb Distal (>10kb) Multiome 866
chr19:48,964,515–48,966,446 192.5 kb Distal (>10kb) Multiome 1015
chr19:48,992,571–48,994,129 164.2 kb Distal (>10kb) Multiome 852
chr19:49,017,642–49,018,292 139.9 kb Distal (>10kb) Multiome 480
chr19:49,019,277–49,019,889 138.2 kb Distal (>10kb) Multiome 233
chr19:49,055,975–49,056,714 101.5 kb Distal (>10kb) Multiome 431
chr19:49,064,668–49,065,682 92.6 kb Distal (>10kb) Multiome 226
chr19:49,071,761–49,072,903 85.8 kb Distal (>10kb) Multiome 278
chr19:49,084,646–49,086,115 72.4 kb Distal (>10kb) Multiome 1030
chr19:49,113,727–49,115,240 42.7 kb Distal (>10kb) Multiome 746
chr19:49,118,477–49,120,300 38.6 kb Distal (>10kb) Multiome 949
chr19:49,127,647–49,128,949 29.6 kb Distal (>10kb) Multiome 1000
chr19:49,129,106–49,129,678 28.2 kb Distal (>10kb) Multiome 197
chr19:49,132,975–49,134,197 24.3 kb Distal (>10kb) Multiome 179
chr19:49,142,781–49,143,252 14.7 kb Distal (>10kb) Multiome 299
chr19:49,145,727–49,146,720 11.5 kb Distal (>10kb) Multiome 511
chr19:49,148,659–49,150,947 7.2 kb Proximal (<10kb) Multiome 917
chr19:49,151,539–49,152,548 5.8 kb Proximal (<10kb) Multiome 497
chr19:49,157,555–49,158,336 22 bp At TSS Multiome 599
chr19:49,210,032–49,211,225 52.8 kb Distal (>10kb) Multiome 366
chr19:49,337,997–49,340,482 181.4 kb Distal (>10kb) Multiome 612
chr19:49,361,283–49,362,837 203.8 kb Distal (>10kb) Multiome 553
chr19:49,362,970–49,364,306 205.9 kb Distal (>10kb) Multiome 616
chr19:49,403,611–49,404,247 246.2 kb Distal (>10kb) Multiome 305
chr19:49,432,343–49,432,785 274.8 kb Distal (>10kb) Multiome 103
chr19:49,436,149–49,436,821 278.7 kb Distal (>10kb) Multiome 248
chr19:49,441,067–49,441,861 283.7 kb Distal (>10kb) Multiome 223
chr19:49,442,072–49,444,054 285.2 kb Distal (>10kb) Multiome 914
chr19:49,451,347–49,452,239 294.1 kb Distal (>10kb) Multiome 764
chr19:49,452,723–49,453,850 295.6 kb Distal (>10kb) Multiome 847
chr19:49,476,063–49,476,551 318.6 kb Distal (>10kb) Multiome 244
chr19:49,487,027–49,488,279 329.7 kb Distal (>10kb) Multiome 964
chr19:49,495,613–49,496,661 338.5 kb Distal (>10kb) Multiome 919
chr19:49,500,403–49,501,353 342.9 kb Distal (>10kb) Multiome 405

Genome Browser

Genomic view of the TRPM4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:48,862,000 – 49,511,353
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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