TRPC4AP
transient receptor potential cation channel subfamily C member 4 associated protein | DKFZP727M231, DKFZp586C1223, PPP1R158, TRRP4AP, dJ756N5.2, C20orf188

Enables phosphatase binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in cytosol. Part of Cul4A-RING E3 ubiquitin ligase complex. Is active in Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2 DE-2.40 Developmental clusters: GC1
Biological processes 19 terms
Cul4-RING E3 ubiquitin ligase complex (GO:0080008)Cul4A-RING E3 ubiquitin ligase complex (GO:0031464)Cul4A-RING E3 ubiquitin ligase complex (GO:0031464)Cul4A-RING E3 ubiquitin ligase complex (GO:0031464)calcium channel activity (GO:0005262)calcium ion transmembrane transport (GO:0070588)cytosol (GO:0005829)perinuclear region of cytoplasm (GO:0048471)phosphatase binding (GO:0019902)phosphatase binding (GO:0019902)plasma membrane (GO:0005886)protein binding (GO:0005515)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (GO:0140627)ubiquitin-like ligase-substrate adaptor activity (GO:1990756)
Expression (TPM)
TRPC4AP — as a Regulated Gene

TFs regulating TRPC4AP 0 TFs

Transcription factors with Perturb-seq knockdown data for TRPC4AP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRPC4AP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TRPC4AP

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRPC4AP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr20:34,824,452–34,825,860 267.4 kb Distal (>10kb) Multiome 852
chr20:34,872,384–34,873,259 219.9 kb Distal (>10kb) Multiome 817
chr20:34,874,110–34,874,535 218.5 kb Distal (>10kb) Multiome 357
chr20:34,875,878–34,877,081 216.4 kb Distal (>10kb) Multiome 852
chr20:34,955,039–34,956,224 137.0 kb Distal (>10kb) Multiome 1031
chr20:34,960,537–34,961,054 131.9 kb Distal (>10kb) Multiome 275
chr20:34,979,568–34,980,289 112.9 kb Distal (>10kb) Multiome 149
chr20:35,092,320–35,093,398 25 bp At TSS Multiome 1139
chr20:35,146,563–35,147,734 54.5 kb Distal (>10kb) Multiome 992
chr20:35,171,731–35,172,358 79.2 kb Distal (>10kb) Multiome 383
chr20:35,174,680–35,175,277 82.1 kb Distal (>10kb) Multiome 635
chr20:35,262,839–35,263,582 170.5 kb Distal (>10kb) Multiome HiCAR 336
chr20:35,269,197–35,269,766 176.7 kb Distal (>10kb) Multiome HiCAR 447
chr20:35,277,415–35,278,519 185.2 kb Distal (>10kb) Multiome HiCAR 575
chr20:35,284,235–35,285,360 192.0 kb Distal (>10kb) Multiome 950
chr20:35,303,859–35,304,479 211.2 kb Distal (>10kb) Multiome 484

Genome Browser

Genomic view of the TRPC4AP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr20:34,814,452 – 35,314,479
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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