The protein encoded by this gene is an E3 ubiquitin-protein ligase that binds with miRNAs and maintains the growth and upkeep of embryonic stem cells. This gene also is involved in the G1-S phase transition of the cell cycle. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for TRIM71. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM71 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM71, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:32,569,852–32,571,425 | 247.1 kb | Distal (>10kb) Multiome | 915 | |
| chr3:32,603,070–32,603,802 | 214.6 kb | Distal (>10kb) Multiome | 180 | |
| chr3:32,643,387–32,643,863 | 174.4 kb | Distal (>10kb) Multiome | 118 | |
| chr3:32,684,803–32,685,731 | 132.8 kb | Distal (>10kb) Multiome | 954 | |
| chr3:32,780,031–32,781,873 | 37.0 kb | Distal (>10kb) Multiome | 958 | |
| chr3:32,815,741–32,817,565 | 1.4 kb | Proximal (<10kb) Multiome | 713 | |
| chr3:32,817,693–32,818,871 | at TSS | At TSS | 300 | |
| chr3:32,821,694–32,822,216 | 3.7 kb | Proximal (<10kb) | 171 | |
| chr3:32,842,816–32,844,607 | 25.6 kb | Distal (>10kb) Multiome | 404 | |
| chr3:32,869,123–32,870,147 | 51.8 kb | Distal (>10kb) Multiome | 264 | |
| chr3:32,902,431–32,903,435 | 85.1 kb | Distal (>10kb) Multiome | 296 | |
| chr3:32,998,701–32,999,462 | 181.1 kb | Distal (>10kb) Multiome | 41 | |
| chr3:33,061,228–33,062,289 | 243.8 kb | Distal (>10kb) Multiome | 238 | |
| chr3:33,096,220–33,097,726 | 279.2 kb | Distal (>10kb) Multiome | 905 | |
| chr3:33,113,579–33,114,881 | 296.4 kb | Distal (>10kb) Multiome | 870 |
Genomic view of the TRIM71 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.