Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within negative regulation of canonical NF-kappaB signal transduction. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRIM59. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM59 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM59, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:160,224,325–160,227,043 | 224.3 kb | Distal (>10kb) Multiome | 759 | |
| chr3:160,398,871–160,400,586 | 50.4 kb | Distal (>10kb) Multiome | 790 | |
| chr3:160,448,903–160,450,623 | 101 bp | At TSS Multiome | 864 | |
| chr3:160,455,869–160,456,545 | 6.1 kb | Proximal (<10kb) | 42 | |
| chr3:160,458,248–160,458,449 | 8.5 kb | Proximal (<10kb) | 35 | |
| chr3:160,564,297–160,566,417 | 115.8 kb | Distal (>10kb) Multiome | 933 | |
| chr3:160,676,210–160,677,318 | 227.0 kb | Distal (>10kb) Multiome | 203 |
Genomic view of the TRIM59 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.