Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPP complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRAPPC5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAPPC5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAPPC5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:7,394,774–7,395,629 | 285.8 kb | Distal (>10kb) Multiome | 601 | |
| chr19:7,482,657–7,483,489 | 197.7 kb | Distal (>10kb) Multiome | 201 | |
| chr19:7,488,712–7,489,463 | 191.8 kb | Distal (>10kb) Multiome | 542 | |
| chr19:7,500,843–7,501,401 | 179.7 kb | Distal (>10kb) Multiome | 556 | |
| chr19:7,505,850–7,507,270 | 174.3 kb | Distal (>10kb) Multiome | 516 | |
| chr19:7,507,812–7,508,356 | 172.8 kb | Distal (>10kb) Multiome | 168 | |
| chr19:7,522,263–7,523,208 | 158.3 kb | Distal (>10kb) Multiome | 917 | |
| chr19:7,533,976–7,536,472 | 146.9 kb | Distal (>10kb) Multiome | 882 | |
| chr19:7,550,673–7,551,762 | 129.5 kb | Distal (>10kb) Multiome | 377 | |
| chr19:7,554,651–7,555,821 | 125.6 kb | Distal (>10kb) Multiome | 224 | |
| chr19:7,595,485–7,596,417 | 85.1 kb | Distal (>10kb) Multiome | 405 | |
| chr19:7,629,285–7,629,891 | 51.2 kb | Distal (>10kb) Multiome | 650 | |
| chr19:7,636,753–7,637,571 | 43.8 kb | Distal (>10kb) Multiome | 689 | |
| chr19:7,680,480–7,681,546 | 94 bp | At TSS Multiome | 679 | |
| chr19:7,681,741–7,681,984 | 867 bp | At TSS | 374 | |
| chr19:7,682,104–7,682,340 | 1.2 kb | Proximal (<10kb) | 148 | |
| chr19:7,829,238–7,830,666 | 149.0 kb | Distal (>10kb) Multiome | 621 | |
| chr19:7,853,168–7,853,781 | 172.6 kb | Distal (>10kb) Multiome | 747 | |
| chr19:7,861,607–7,864,383 | 181.8 kb | Distal (>10kb) Multiome | 348 | |
| chr19:7,868,454–7,870,252 | 188.6 kb | Distal (>10kb) Multiome | 721 | |
| chr19:7,871,072–7,872,772 | 191.2 kb | Distal (>10kb) Multiome | 487 | |
| chr19:7,873,962–7,875,061 | 193.7 kb | Distal (>10kb) Multiome | 416 | |
| chr19:7,888,334–7,888,798 | 207.6 kb | Distal (>10kb) Multiome | 509 | |
| chr19:7,902,730–7,904,931 | 222.9 kb | Distal (>10kb) Multiome | 1000 | |
| chr19:7,917,358–7,918,182 | 237.1 kb | Distal (>10kb) Multiome | 316 | |
| chr19:7,919,934–7,921,640 | 239.8 kb | Distal (>10kb) Multiome | 802 | |
| chr19:7,924,612–7,926,698 | 244.4 kb | Distal (>10kb) Multiome | 766 | |
| chr19:7,943,338–7,944,472 | 263.0 kb | Distal (>10kb) Multiome | 974 |
Genomic view of the TRAPPC5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.