Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of protein localization to kinetochore; and regulation of kinetochore assembly. Located in several cellular components, including endoplasmic reticulum-Golgi intermediate compartment; kinetochore; and perinuclear region of cytoplasm. Part of TRAPP complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRAPPC12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAPPC12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAPPC12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:1,823,112–1,823,997 | 1556.2 kb | Distal (>10kb) Multiome HiCAR | 143 | |
| chr2:3,265,176–3,267,080 | 113.6 kb | Distal (>10kb) Multiome | 214 | |
| chr2:3,302,656–3,304,274 | 76.0 kb | Distal (>10kb) Multiome | 611 | |
| chr2:3,377,329–3,378,629 | 1.8 kb | Proximal (<10kb) Multiome | 975 | |
| chr2:3,379,318–3,380,419 | 34 bp | At TSS Multiome | 1029 | |
| chr2:3,482,920–3,483,746 | 103.7 kb | Distal (>10kb) Multiome | 137 | |
| chr2:3,518,104–3,520,209 | 139.5 kb | Distal (>10kb) Multiome | 1083 | |
| chr2:3,557,826–3,559,338 | 178.7 kb | Distal (>10kb) Multiome | 1106 | |
| chr2:3,574,766–3,576,282 | 195.5 kb | Distal (>10kb) Multiome | 1145 | |
| chr2:3,650,709–3,651,305 | 271.5 kb | Distal (>10kb) Multiome | 403 | |
| chr2:3,651,453–3,652,406 | 272.4 kb | Distal (>10kb) Multiome | 610 |
Genomic view of the TRAPPC12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.