The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]
Transcription factors with Perturb-seq knockdown data for TRAFD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAFD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAFD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:111,841,636–111,842,766 | 283.5 kb | Distal (>10kb) Multiome | 963 | |
| chr12:111,967,710–111,968,344 | 157.4 kb | Distal (>10kb) Multiome | 26 | |
| chr12:112,012,418–112,014,496 | 112.2 kb | Distal (>10kb) Multiome | 1077 | |
| chr12:112,108,135–112,109,541 | 16.7 kb | Distal (>10kb) Multiome | 788 | |
| chr12:112,116,420–112,116,883 | 8.8 kb | Proximal (<10kb) Multiome | 549 | |
| chr12:112,125,273–112,125,989 | 46 bp | At TSS Multiome | 798 | |
| chr12:112,381,577–112,382,895 | 256.9 kb | Distal (>10kb) Multiome | 774 | |
| chr12:112,409,112–112,409,791 | 284.0 kb | Distal (>10kb) Multiome | 866 | |
| chr12:112,418,542–112,419,596 | 293.5 kb | Distal (>10kb) Multiome | 960 |
Genomic view of the TRAFD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.