Enables Wnt-protein binding activity and metalloendopeptidase activity. Involved in several processes, including negative regulation of Wnt signaling pathway; positive regulation of protein oxidation; and positive regulation of protein-containing complex assembly. Located in nucleoplasm; organelle membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for TRABD2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRABD2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRABD2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:47,708,607–47,710,278 | 287.9 kb | Distal (>10kb) Multiome | 464 | |
| chr1:47,724,839–47,725,636 | 272.2 kb | Distal (>10kb) Multiome | 184 | |
| chr1:47,948,155–47,948,873 | 49.0 kb | Distal (>10kb) Multiome | 161 | |
| chr1:47,983,776–47,984,855 | 13.1 kb | Distal (>10kb) Multiome | 157 | |
| chr1:47,992,446–47,993,200 | 4.2 kb | Proximal (<10kb) | 100 | |
| chr1:47,996,187–47,998,080 | 263 bp | At TSS Multiome | 504 | |
| chr1:48,024,695–48,025,655 | 27.8 kb | Distal (>10kb) Multiome | 216 | |
| chr1:48,051,694–48,052,373 | 54.7 kb | Distal (>10kb) Multiome HiCAR | 82 | |
| chr1:48,068,111–48,069,002 | 71.0 kb | Distal (>10kb) Multiome HiCAR | 109 | |
| chr1:48,073,607–48,074,075 | 76.5 kb | Distal (>10kb) Multiome HiCAR | 90 | |
| chr1:48,208,078–48,209,322 | 211.5 kb | Distal (>10kb) Multiome HiCAR | 64 | |
| chr1:48,214,255–48,215,241 | 217.2 kb | Distal (>10kb) Multiome | 110 |
Genomic view of the TRABD2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.