Enables importin-alpha family protein binding activity; molecular adaptor activity; and protein kinase binding activity. Involved in activation of protein kinase activity; microtubule cytoskeleton organization; and negative regulation of microtubule depolymerization. Located in intercellular bridge; nucleoplasm; and spindle. Is active in spindle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for TPX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:31,514,040–31,515,233 | 224.8 kb | Distal (>10kb) Multiome | 1014 | |
| chr20:31,572,435–31,573,822 | 166.1 kb | Distal (>10kb) Multiome | 1193 | |
| chr20:31,595,608–31,596,479 | 143.3 kb | Distal (>10kb) Multiome | 676 | |
| chr20:31,604,042–31,606,325 | 135.1 kb | Distal (>10kb) Multiome | 1198 | |
| chr20:31,606,499–31,608,983 | 130.6 kb | Distal (>10kb) Multiome | 1081 | |
| chr20:31,612,623–31,613,367 | 126.3 kb | Distal (>10kb) Multiome | 858 | |
| chr20:31,661,610–31,662,406 | 77.5 kb | Distal (>10kb) Multiome | 836 | |
| chr20:31,693,987–31,694,929 | 44.9 kb | Distal (>10kb) Multiome | 357 | |
| chr20:31,722,556–31,724,276 | 15.6 kb | Distal (>10kb) Multiome | 1147 | |
| chr20:31,738,777–31,739,576 | 71 bp | At TSS Multiome | 923 | |
| chr20:31,822,496–31,823,111 | 83.7 kb | Distal (>10kb) Multiome | 479 | |
| chr20:31,860,463–31,862,362 | 122.5 kb | Distal (>10kb) Multiome | 627 | |
| chr20:31,870,005–31,870,863 | 131.1 kb | Distal (>10kb) Multiome | 460 | |
| chr20:31,879,388–31,880,438 | 140.6 kb | Distal (>10kb) Multiome | 900 | |
| chr20:31,951,523–31,952,606 | 212.8 kb | Distal (>10kb) Multiome | 879 | |
| chr20:31,967,880–31,968,893 | 229.2 kb | Distal (>10kb) Multiome | 1059 | |
| chr20:31,972,125–31,972,938 | 233.2 kb | Distal (>10kb) Multiome | 252 | |
| chr20:32,017,795–32,019,711 | 279.1 kb | Distal (>10kb) Multiome | 611 | |
| chr20:32,031,048–32,031,781 | 292.3 kb | Distal (>10kb) Multiome | 627 |
Genomic view of the TPX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.